| A Facile and Highly Stereoselective Reductive Dcbromination of AnhydrO-6- (R)-Hydroxyethyl- 6-Bromopenicillin |
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| 引用本文： | Bing ZHENG,Jin Long WU, Shao Jun XU, Jian Feng SHI, Yao Zu CHEN (Department of Chemistry,Zhejiang University,Hangzhou 310027 National Laboratory of Applied Organic Chemistry.Lanzhou 730000). A Facile and Highly Stereoselective Reductive Dcbromination of AnhydrO-6- (R)-Hydroxyethyl- 6-Bromopenicillin[J]. 中国化学快报, 2000, 0(5) |
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| 作者姓名： | Bing ZHENG Jin Long WU Shao Jun XU Jian Feng SHI Yao Zu CHEN (Department of Chemistry Zhejiang University Hangzhou 310027 National Laboratory of Applied Organic Chemistry.Lanzhou 730000) |
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| 作者单位： | Department of Chemistry，Zhejiang University，Hangzhou 310027 National Laboratory of Applied Organic Chemistry.Lanzhou 730000 |
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| 摘 要： | Thetitlecompound,4-acetoxyazetidinone5',hasbeenwidelyusedasanimportantintermediateforpenem,carbapenemandtrinemsynthesisZa~Zfandseveralapproachesto5havebeenreported3a~3c.Thesemisyntheticapproachof4-acetoxyazetidinone5frompenicillinIreportedbyDiNinnoetal.Zbisausefulone,thedebrominationofmethyl6-bromo-6-l(R)-Ihydroxy-ethyllpenicillinate3byzinc-ammoniumacetateaffordedthelabilecompound4.91igmixtureoftransandetsisomers,in92%yieldbutintheformerstepthehydroxyethylationoftheC-6positionofpenicillinat…
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A Facile and Highly Stereosclective Reductive Dcbromination of AnhydrO-6- (R)-Hydroxyethyl- 6-Bromopenicillin |
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| Bing ZHENG,Jin Long WU, Shao Jun XU, Jian Feng SHI, Yao Zu CHEN. A Facile and Highly Stereosclective Reductive Dcbromination of AnhydrO-6- (R)-Hydroxyethyl- 6-Bromopenicillin[J]. Chinese Chemical Letters, 2000, 0(5) |
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| Authors: | Bing ZHENG Jin Long WU Shao Jun XU Jian Feng SHI Yao Zu CHEN |
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| Abstract: | |
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| Keywords: | Reductive debromination. stereoselcctivity. anhydro-6-(R)-hydroxyethyl-6-bromo- penicillin. |
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