| Et_2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α-hydroxy Taxinine B |
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| 作者姓名： | Qian CHENG Takayuki ORITANI Tohru HORIGUCHI |
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| 作者单位： | Laboratory of Applied Bioorganic Chemistry，Graduate School of Agricultural Science Tohoku University，1 -1 Tsutsumidori-Amamiyamachi，Aoba-ku，Sendai 981，Japan. |
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| 基金项目： | Giant-in-Aid for scientific reserch from the Ministry of Education, Science and Culture of Japan，JSPS fellowship to DL Q. Che |
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| 摘 要： | The anticancer drug paclitaxel (Taxol@), a diterpenoid isolated from the bark of Taxusbrevghlia', is clinically used in the treatment of ovarian and breast cancers2. Since itsdiscovery in the 1960s, particularly in recent years, a large number of studies onchemistry and structure-activity relationship have been carried out and led to the generalconclusion that the function groups at C,, C,, C.,, C,.-,, and C,-CH, have modest butoften beneficial effects on its biological activity, while the …
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Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B |
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| Qian CHENG,Takayuki ORITANI,Tohru HORIGUCHI.Et2AlCl-Mediated Reaction of α-4(20)-Epoxy-5α -hydroxy Taxinine B[J].Chinese Chemical Letters,2000,11(3). |
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| Authors: | Qian CHENG Takayuki ORITANI Tohru HORIGUCHI |
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| Abstract: | An α-4(20)-epoxy-5α -hydroxytaxinine β 1, when treated with diethylaluminum chloride, underwent reactions involving intramolecular substitution along with deacetylation or addition leading to new rings. Two novel 1-deoxy compounds 2 and 3 were isolated and fully characterized. |
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| Keywords: | Antitumour compounds taxoides epoxide diethylaluminum chloride |
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