| Preparation of AChE Inhibitors From Jujubogenin |
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| 引用本文： | Yu ZHAO,Yuan Ling KU,Shoei Sheng LEE (Laboratory of Phytochemistry,Kunnming Institute of Botany,Chinese Academy of Sciences,Kunming 650204, School of Pharmacy,College of Medicine,National Taiwan University,Taipei 10018). Preparation of AChE Inhibitors From Jujubogenin[J]. 中国化学快报, 2000, 0(8) |
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| 作者姓名： | Yu ZHAO Yuan Ling KU Shoei Sheng LEE (Laboratory of Phytochemistry Kunnming Institute of Botany Chinese Academy of Sciences Kunming 650204 School of Pharmacy College of Medicine National Taiwan University Taipei 10018) |
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| 作者单位： | Laboratory of Phytochemistry，Kunnming Institute of Botany，Chinese Academy of Sciences，Kunming 650204; School of Pharmacy，College of Medicine，National Taiwan University，Taipei 10018 |
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| 摘 要： | The advanced medical technology has lengthened the life expectancy of human beings.This makes some previously ignored diseases prominent, such as Alzheimer disease(AD). The low level of acetylcholine (ACh) in brain is considered to be one of mainreasons for suffering such memory loss disease. Thereby, how to elevate ACh level inbrain and enhance the cognition has become a main issue l'2. One of the approaches is toinvestigate acetylcholinesterase (AChE) inhibitors, which can prevent the hy…
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Preparation of AChE Inhibitors From Jujubogenin |
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| Yu ZHAO,Yuan Ling KU,Shoei Sheng LEE. Preparation of AChE Inhibitors From Jujubogenin[J]. Chinese Chemical Letters, 2000, 0(8) |
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| Authors: | Yu ZHAO Yuan Ling KU Shoei Sheng LEE |
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| Abstract: | A dammarane derivative dihydrojujubogenin-2 -en- 1 -one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The anti-AChE activity of this compound and related analogue was measured. |
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| Keywords: | Alzheimer disease (AD) acetylcholinesterase (AChE) inhibitor pharmaceutical chemistry jujubogenin Territrem B analogues. |
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