Synthesis of the macrocyclic core of leiodermatolide |
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Authors: | Paterson Ian Paquet Tanya Dalby Stephen M |
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Affiliation: | University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. ip100@cam.ac.uk |
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Abstract: | The macrocyclic core (2) of the marine macrolide leiodermatolide (1) has been synthesized in 19 steps through a convergent strategy exploiting boron aldol methodology to install the requisite stereochemistry and a selective Stille coupling reaction for controlled fragment assembly, followed by a Yamaguchi macrolactonization and carbamate introduction at the C9-OH. |
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