| Oxyfunctionalization of ketones bearing α-methylene group with piperidine oxoammonium salt.Synthesis of α-diketones from monoketones |
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| 作者姓名： | LIU You-Cheng REN Tan GUO Qing-Xiang National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Gansu China |
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| 作者单位： | LIU，You-Cheng REN，Tan GUO，Qing-Xiang National Laboratory of Applied Organic Chemistry，Lanzhou University，Lanzhou，Gansu 730000，China Department of Modern Chemistry，University of Science and Technology of China，Hefei，Anhui 230026，China |
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| 基金项目： | Project supported by the National Natural Science Foundation of China. |
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| 摘 要： | A facile method for the title transformation is described. The reaction of 2,2,6,6-tetramethyl-4-methoxypiperidine oxoammonium chloride (1b) and ketones bearing a-methylene group in acetonitrile proceeded smoothly to give the a-oxyfunctionalized coupling products (6a-h). These coupling products decomposed upon heating in acidic medium to produce a-diketones (7a-h) in good to excellent yields.
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| 关 键 词： | Piperidine oxoammonium salt monoketones α-diketones synthesis |
Oxyfunctionalization of ketones bearing α-methylene group with piperidine oxoammonium salt. Synthesis of α-diketones from monoketones |
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| LIU,You-Cheng REN,Tan GUO,Qing-Xiang National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu ,China.Oxyfunctionalization of ketones bearing α-methylene group with piperidine oxoammonium salt. Synthesis of α-diketones from monoketones[J].Chinese Journal of Chemistry,1996,14(3):252-258. |
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| Authors: | LIU You-Cheng REN Tan GUO Qing-Xiang National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou Gansu China |
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| Institution: | LIU,You-Cheng REN,Tan GUO,Qing-Xiang National Laboratory of Applied Organic Chemistry,Lanzhou University,Lanzhou,Gansu 730000,China Department of Modern Chemistry,University of Science and Technology of China,Hefei,Anhui 230026,China |
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| Abstract: | A facile method for the title transformation is described. The reaction of 2,2,6,6-tetramethyl-4-methoxypiperidine oxoammonium chloride (1b) and ketones bearing a-methylene group in acetonitrile proceeded smoothly to give the a-oxyfunctionalized coupling products (6a-h). These coupling products decomposed upon heating in acidic medium to produce a-diketones (7a-h) in good to excellent yields. |
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| Keywords: | Piperidine oxoammonium salt monoketones α-diketones synthesis |
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