| 手性吲哚啉衍生物合成方法的研究进展 |
| |
| 引用本文： | 张宝乐,秦伟,段迎超,余斌,张恩,刘宏民.手性吲哚啉衍生物合成方法的研究进展[J].有机化学,2012,31(8):1359-1367. |
| |
| 作者姓名： | 张宝乐 秦伟 段迎超 余斌 张恩 刘宏民 |
| |
| 作者单位： | 1. 郑州大学药学院 郑州450001
2. 齐齐哈尔医学院药学院 齐齐哈尔161000 |
| |
| 基金项目： | 国家自然科学基金(No.81172937);中国博士后科学基金(No.20100480857);中国博士后特别资助基金(No.201104402)资助项目~~ |
| |
| 摘 要： | 吲哚啉衍生物广泛存在于自然界中,因具有多种生物学活性而引起广泛关注.近年来,手性吲哚啉衍生物成为此领域的研究热点,也报道了多种相应的合成方法,主要包括动力学拆分、不对称合成、手性合成子策略等,不对称Domino级联反应作为近年来发展较快的领域,也引起了广泛关注,对以上合成方法加以综述.
|
| 关 键 词： | 吲哚啉 不对称 合成 |
Recent Development on the Synthetic Methods of Chiral Indoline Derivatives |
| |
| Zhang Baole
,
Qin Wei
,
Duan Yingchao
,
Yu Bin
,
Zhang En
,
Liu Hongmin.Recent Development on the Synthetic Methods of Chiral Indoline Derivatives[J].Chinese Journal of Organic Chemistry,2012,31(8):1359-1367. |
| |
| Authors: | Zhang Baole Qin Wei Duan Yingchao Yu Bin Zhang En Liu Hongmin |
| |
| Institution: | Zhang,Baolea Qin,Weib Duan,Yingchaoa Yu,Bina Zhang,Ena Liu,Hongmin,a(aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001)(bSchool of Pharmacy,Qiqihar Medical University,Qiqihaer 161000) |
| |
| Abstract: | The indoline skeletons,widely present in alkaloids and other products with diverse biological activities,which also have been considered as privileged structures due to their widespread use as building blocks and chiral auxiliaries in asymmetric synthesis.The importance of these motifs has determined that numerous synthetic multi-step strategies have been developed.Consequently,there has been a continuing interest in the development of efficient methods to obtain enantioenriched substituted indolines.A lot of methods have been introduced,including dynamic kinetic resolution,asymmetric reactions,asymmetric domino cascade reactions and other novel reactions.These methods have been reviewed. |
| |
| Keywords: | indoline asymmetric synthesis |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
