| Study on the Total Synthesis of Et 743 and its Analogues： Synthesis of a Tricyclic Intermediate and its 11-Epimer |
| |
| 作者姓名： | YeFengTANG ZhanZhuLIU ShiZhiCHEN |
| |
| 作者单位： | Ye Feng TANG，Zhan Zhu LIU，Shi Zhi CHEN
Institute of Materia Medica，Chinese Academy of Medical Sciences & Peking Union Medical
College，Beijing 100050 |
| |
| 摘 要： | The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agen4 but not when BOP-Cl used in the same reaction. The stereochemistry of both isomers was confirmed on basis of the ^1H NMR and NOE-difference spectra.
|
| 关 键 词： | 合成 Et743 三环化合物 立体化学 11-异构体 中间体 邻苯二甲酸丁基辛酯 耦合试剂 杂环化合物 |
Study on the Total Synthesis of Et 743 and its Analogues:Synthesis of a Tricyclic Intermediate and its 11-Epimer |
| |
| YeFengTANG ZhanZhuLIU ShiZhiCHEN.Study on the Total Synthesis of Et 743 and its Analogues:Synthesis of a Tricyclic Intermediate and its 11-Epimer[J].Chinese Chemical Letters,2003,14(10):996-998. |
| |
| Authors: | Ye Feng TANG Zhan Zhu LIU Shi Zhi CHEN |
| |
| Abstract: | The tricyclic compound 1, a key intermediate of the pentacyclic core of Et 743 and its analogues, was synthesized. Its 11-epimer was found as the product of racemization when BOP was used as the coupling agent, but not when BOP-C1 used in the same reaction. The stereochemistry of both isomers was confirmed on basis of the 1H NMR and NOE-difference spectra. |
| |
| Keywords: | Et 743 tricyclic compound synthesis stereochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
