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Antioxidant properties of water-soluble amino acid derivatives of fullerenes and their role in the inhibition of herpes virus infection |
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| Authors: | Kotel’nikova R. A. Faingol’d I. I. Poletaeva D. A. Mishchenko D. V. Romanova V. S. Shtol’ko V. N. Bogdanov G. N. Rybkin A. Yu. Frog E. S. Smolina A. V. Kushch A. A. Fedorova N. E. Kotel’nikov A. I. |
| Affiliation: | 1.Institute of Problems of Chemical Physics, Russian Academy of Sciences, 1 prosp. Akad. Semenova, 142432, Chernogolovka, Moscow Region, Russian Federation ;2.A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 ul. Vavilova, 119991, Moscow, Russian Federation ;3.D. I. Ivanovsky Institute of Virusology, Ministry of Health Protection and Social Development of the Russian Federation, 16 ul. Gamalei, 123098, Moscow, Russian Federation ; |
| Abstract: | The antioxidant properties of water-soluble amino acid derivatives of fullerene C60 (ADF) were studied. It was shown by the change in the concentration of malonic dialdehyde in rat brain mitochondria that the ADF are antioxidants. They were shown by the change in the luminol glow to possess antiradical activity, which is determined by the acceptor properties of the fullerene spheroid and is independent of the structure of the attached addends. Stereoselectivity of the antioxidant properties of the enantiomers of amino acid derivatives of fullerene C60 was found. The L-isomers of ADF inhibit lipid peroxidation, whereas the D-isomers do not inhibit. A reliable correlation between the development of cytomegalovirus (CMV) infection and the process of lipid peroxidation in the cell culture was established. An efficient inhibitor of the CMV infection from the class of amino acid derivatives of fullerene with antioxidant activity was obtained. |
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