Determination of rifampicin based on fluorescence quenching of GSH capped CdTe/ZnS QDs |
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Authors: | Zhengqing Liu Pengfei Yin Huiping Gong Pingping Li Xiaodan Wang Youqiu He |
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Affiliation: | School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China |
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Abstract: | Aqueous glutathione (GSH)-capped CdTe/ZnS QDs with the diameter of 3–4 nm were synthesized. The fluorescence of CdTe/ZnS QDs at 577 nm was quenched in the presence of rifampicin (Rfp), with excitation wavelength at 350 nm. The mechanism of the interaction of CdTe/ZnS QDs with Rfp was investigated. Under the optimal conditions, the calibration plot of ln(F0/F) was linear in the range 0.83–56 μg mL?1 with concentration of Rfp, and the detection limit was 0.25 μg mL?1. The proposed method was successfully applied to the determination of Rfp in its commercial capsules, and satisfactory results were obtained. The recovery of the method was in the range 98.6–103.2%. |
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