Simultaneous determination of thirty non-steroidal anti-inflammatory drug residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry |
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| Authors: | Ting Hu Tao Peng Xiao-Juan Li Dong-Dong Chen Han-Hui Dai Xiao-Jun Deng Zhen-Feng Yue Guo-Min Wang Jian-Zhong Shen Xi Xia Shuang-Yang Ding Yue-Ning Zhou Ai-Ling Zhu Hai-Yang Jiang |
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| Affiliation: | 1. College of Veterinary Medicine, China Agricultural University, Beijing 100193, China;2. Chinese Academy of Inspection and Quarantine, Beijing 100123, China;3. Shanghai Entry-Exit Inspection and Quarantine Bureau, Shanghai 200135, China;4. Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, China;5. Chongqing Entry-Exit Inspection and Quarantine Bureau, Chongqing 400020, China;6. College of Chemistry and Chemical Engineering of Shanxi University, Taiyuan, 030006, China |
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| Abstract: | An ultra-high-performance liquid chromatography with tandem mass spectrometric detection (UHPLC–MS/MS) method was established for the simultaneous determination of residues of thirty non-steroidal anti-inflammatory drugs (NSAIDs) in swine muscle. The samples were extracted with acetonitrile and phosphoric acid. The extracts were defatted with n-hexane, and then purified by HLB solid-phase extraction cartridge. Analysis was carried out on UHPLC–ESI-MS/MS working with multiple reaction monitoring mode with polarity switching. Limits of detection were between 0.4 μg/kg and 2.0 μg/kg, and limits of quantification were between 1.0 μg/kg and 5.0 μg/kg. The recoveries of NSAIDs were between 61.7% and 125.7% at spiked levels of 1.0–500 μg/kg. The repeatability was less than 8% and the within-laboratory reproducibility was not more than 12.3%. The method was reliable, convenient and sensitive. |
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