Synthesis,structutre and biological activity of substituted [16α,17α]cyclopropapregn-4-ene-3,20-diones |
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| Authors: | I. S. Levina L. E. Kulikova E. V. Shulishov Yu. V. Tomilov A. N. Smirnov |
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| Affiliation: | 1. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991, Moscow, Russian Federation
2. Faculty of Biology, M. V. Lomonosov Moscow State University, 1/12 Leninskie Gory, 119992, Moscow, Russian Federation
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| Abstract: | Aryldiazomethanes generated by vacuum thermolysis of arenecarbaldehyde tosylhydrazone sodium salts react stereospecifically with 16-dehydropregnenolone acetate. Subsequent decomposition of the pyrazoline adducts yielded hitherto unknown substituted [16α,17α]-cyclopropaprogesterones bearing the aryl substituents at the position 3′. Interaction of such cyclopropaprogesterones with progesterone receptor from rat uterine cytosol was studied. |
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