Mathematical Model and Numerical Simulation of Conductometric Biosensor of Urea |
| |
Authors: | Fares Zouaoui Nadia Zine Abdelhamid Errachid Nicole Jaffrezic-Renault |
| |
Affiliation: | University of Lyon, Institute of Analytical Sciences, UMR 5280, CNRS, 69100 Villeurbanne, France |
| |
Abstract: | In this article, a mathematical model was developed to describe and optimize the configuration of the urea biosensor. The biosensor is based on interdigitated gold microelectrodes modified with a urease enzyme membrane. The model presented here focuses on the enzymatic reaction and/or diffusion phenomena that occur in the enzyme membrane and in the diffusion layer. Numerical resolution of differential equations was performed using the finite difference technique. The mathematical model was validated using experimental biosensor data. The responses of the biosensor to various conditions were simulated to guide experiments, improve analytical performance, and reduce development costs. |
| |
Keywords: | Conductometry urea urease modelling analytical performance |
|
|