| Institution: | 1. Ankara University, Department of Chemistry, 06100, Beşevler Ankara, Turkey;2. Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560 Ankara, Turkey
Department of Analytical Chemistry, Faculty of Pharmacy, Adıyaman University, Turkey;3. DEVA Holding A.Ş., R&D Center, Karaağaç Mh., Fatih Blv. No: 26, 59510 Kapaklı, Tekirdağ, Turkey;4. Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560 Ankara, Turkey |
| Abstract: | Ruxolitinib (RUX), a compound of the pyrrolopyrimidines class with activity as a tyrosine kinase inhibitory drug, is used to treat myelofibrosis. This study is reported for the detailed electrochemical behavior of RUX. The effects of supporting electrolyte, pH, and scanning rate on the peak potentials and currents of RUX were investigated by BDDE and GCE using different voltammetric techniques. Under optimum experimental conditions, calibration curves for RUX were obtained as 4 μM–80 μM and 1 μM–80 μM with a limit of detection (LOD) of 0.517 μM and 0.192 μM by the GCE and BDDE, respectively using DPV. |
