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Electrochemical Investigation of Ruxolitinib: Sensitive Voltammetric Assay in Drug Product and Human Serum by Using Different Solid Electrodes
Authors:Selva Bilge  Leyla Karadurmus  Esen Bellur Atici  Ali Sınağ  Sibel A Ozkan
Institution:1. Ankara University, Department of Chemistry, 06100, Beşevler Ankara, Turkey;2. Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560 Ankara, Turkey

Department of Analytical Chemistry, Faculty of Pharmacy, Adıyaman University, Turkey;3. DEVA Holding A.Ş., R&D Center, Karaağaç Mh., Fatih Blv. No: 26, 59510 Kapaklı, Tekirdağ, Turkey;4. Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, 06560 Ankara, Turkey

Abstract:Ruxolitinib (RUX), a compound of the pyrrolopyrimidines class with activity as a tyrosine kinase inhibitory drug, is used to treat myelofibrosis. This study is reported for the detailed electrochemical behavior of RUX. The effects of supporting electrolyte, pH, and scanning rate on the peak potentials and currents of RUX were investigated by BDDE and GCE using different voltammetric techniques. Under optimum experimental conditions, calibration curves for RUX were obtained as 4 μM–80 μM and 1 μM–80 μM with a limit of detection (LOD) of 0.517 μM and 0.192 μM by the GCE and BDDE, respectively using DPV.
Keywords:Ruxolitinib  voltammetry  glassy carbon electrode  boron-doped diamond electrode  method validation  mechanism
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