Two-layered Au@Ag Bimetallic Nanocomposites-poly (L-Met) Platform for Highly Sensitive Chlorpheniramine Maleate Detection

The two-layered bimetallic Au@Ag and poly(L-methionine) (Au@Ag/p-L-met) sensor was newly developed for the electrochemical determination of chlorpheniramine maleate (CPM). After electropolymerization of L-met, bimetallic surfaces were prepared by electrodeposition of Au@Ag nanoparticles on the p-L-met/PGE. The surface characterization was carried out by scanning electron microscopy (SEM), Energy Dispersive X-ray spectroscopy (EDX), Cyclic Voltammetry (CV) and Electrochemical impedance spectroscopy (EIS). The sensor shows good electrocatalytic activity, high sensitivity, wide linear range (0.87–600.0 μM) and a low detection limit (0.26 μM) by using Differential pulse voltammetry (DPV). The sensor was used to determine CPM in pharmaceutical samples with satisfactory results.