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The multi-concentration and two-dimensional capillary electrophoresis method for the analysis of drugs in urine samples |
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| Authors: | ZHANG ZhaoXiang ZHANG XiaoWei & LI Feng Key Laboratory of Eco-Chemical Engineering Ministry of Education College of Chemistry Molecular Engineering Qingdao University of Science Technology Qingdao China School of Science Qingdao Technological University Qingdao China |
| Affiliation: | ZHANG ZhaoXiang 1,ZHANG XiaoWei 2 & LI Feng 1 1Key Laboratory of Eco-Chemical Engineering,Ministry of Education,College of Chemistry , Molecular Engineering,Qingdao University of Science , Technology,Qingdao 266042,China 2School of Science,Qingdao Technological University,Qingdao 266033,China |
| Abstract: | A novel method has been developed by integration of multi-concentration and two-dimensional(2D) capillary electrophoresis(CE) for simultaneous enhancement of detection sensitivity and separation power in complex samples.Capillary zone electrophoresis(CZE) was used as the first dimension separation according to mobilities,from which the effluent fractions were further analyzed by micellar electrokinetic capillary chromatography(MEKC) acting as the second dimension.Cation-selective exhaustive injection(CSEI) ... |
| Keywords: | multi-concentration two-dimensional capillary electrophoresis drug pharmacokinetic study |
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