Enantiomers of New Synthetic Pyrrolylphenylethanoneamine Mono-Amino Oxidase Inhibitor Compounds: Analytical and Semipreparative HPLC Separations, and Chiroptical Characteristics |
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Authors: | F La Torre R Cirilli R Costi R Di Santo R Ferretti B Gallinella A Salerno L Zanitti |
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Institution: | (1) Dipartimento di Chimica del Farmaco, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy;(2) Istituto Pasteur-Fondazione Cenci-Bolognetti, Dipartimento di Studi Farmaceutici, Università di, Roma La Sapienza , 00161 Rome, Italy |
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Abstract: | The polysaccharide chiral stationary phases (CSPs) Chiralcel OD and Chiralpak AD, and the brush-type (R,R)-Whelk-01 chiral stationary phases have been evaluated to separate new synthetic pyrrolylphenylethanoneamine racemic compounds, potentially monoamine oxidase (MAO) inhibitors, under various mobile phase compositions, using various temperatures. The enantioseparation was evaluated by comparing the (R,R)-Whelk-01 column performance with those of Chiralpak AD and Chiralcel OD. Significant differences were observed in their chiral recognition, as revealed from their retention, selectivity, resolution and elution order. Performances of the Chiralpak AD column were superior to those of the Chiralcel OD and (R,R)-Whelk-01 columns. Some of the racemic compounds were resolved by semipreparative chromatography on Chiralpak AD column in order to study the chiroptical proprieties of the single enantiomers. |
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Keywords: | Column liquid chromatography Enantiomer separation Chiral stationary phases Chiroptical detection Monoamine oxidase inhibitors |
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