'Double asymmetric induction' as a novel tool for high stereocontrol in Baylis-Hillman reaction |
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| Authors: | Krishna Palakodety Radha Sachwani Rachna Kannan V |
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| Institution: | D-206/B, Discovery Laboratory, Organic Chemistry Division-III Indian Institute of Chemical Technology, Hyderabad 500 007, India. prkgenius@iict.res.in |
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| Abstract: | The strategy of double asymmetric induction was utilized in Baylis-Hillman reaction for the first time by the coupling of chiral aldehydes with chiral acrylate (1,2:5,6-di-O-isopropylidene-alpha-D-glucofuranose-3-acrylate) to obtain corresponding adducts with high syn diastereoselectivities (de >90%) in moderate to good yields. |
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