| Spectrophotometric Determination of Cimetidine through Charge-transfer Reaction with 1,5-Dichloroanthraquinone as a π-Electron Acceptor |
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| 作者姓名： | WEI Xiaoling DU Liangwei WANG Lisheng WEI Chunliu JIANG Zhiliang |
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| 作者单位： | a College of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530000, China ;b Department of Environmental Science, Guangxi Normal University, Guilin, Guangxi 541004, China ; |
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| 摘 要： | Cimetidine reacting with 1,5-dichloroanthraquinone in acetone solution can produce a charge-transfer complex that shows a strong absorption peak at 343 nm. The absorption value at 343 nm increased with cimetidine concentration in the range of 0.01—0.5 μg/mL, with regression coefficient of 0.9995 and detection limit of 0.006 μg/mL. This simple and sensitive method has been successfully applied to determine cimetidine in tablets and capsules, with average recovery of (98.47±0.92)% and (97.07±1.16)%, respectively. Furthermore, the mole ratio of the complex between cimetidine and 1,5-dichloroanthraquinone is 2∶1, and the mechanism of charge-transfer reaction is explored.
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| 关 键 词： | cimetidine 1 5-dichloroanthraquinone charge-transfer reaction UV spectrophotometry |
| 收稿时间： | 2008-12-19 |
| 修稿时间： | 2009-4-10 |
Spectrophotometric Determination of Cimetidine through Charge‐transfer Reaction with 1,5‐Dichloroanthraquinone as a π‐Electron Acceptor |
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| WEI Xiaoling,DU Liangwei,WANG Lisheng,WEI Chunliu,JIANG Zhiliang.Spectrophotometric Determination of Cimetidine through Charge‐transfer Reaction with 1,5‐Dichloroanthraquinone as a π‐Electron Acceptor[J].Chinese Journal of Chemistry,2009,27(8):1624-1628. |
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| Authors: | Xiaoling WEI Liangwei DU Lisheng WANG Chunliu WEI Zhiliang JIANG |
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| Institution: | 1. Tel.: 0086‐0771‐3236316;2. College of Chemistry and Chemical Engineering, Guangxi University, Nanning, Guangxi 530000, China;3. Department of Environmental Science, Guangxi Normal University, Guilin, Guangxi 541004, China |
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| Abstract: | Cimetidine reacting with 1,5‐dichloroanthraquinone in acetone solution can produce a charge‐transfer complex that shows a strong absorption peak at 343 nm. The absorption value at 343 nm increased with cimetidine concentration in the range of 0.01–0.5 µg/mL, with regression coefficient of 0.9995 and detection limit of 0.006 µg/mL. This simple and sensitive method has been successfully applied to determine cimetidine in tablets and capsules, with average recovery of (98.47±0.92)% and (97.07±1.16)%, respectively. Furthermore, the mole ratio of the complex between cimetidine and 1,5‐dichloroanthraquinone is 2:1, and the mechanism of charge‐transfer reaction is explored. |
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| Keywords: | cimetidine 1 5‐dichloroanthraquinone charge‐transfer reaction UV spectrophotometry |
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