How to prepare a chiral Grignard reagent: a theoretical proposal |
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| Authors: | Chen Zhe-Ning Fu Gang Xu Xin |
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| Affiliation: | State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. |
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| Abstract: | It is shown that two competitive pathways (T2 vs T4) exist for Grignard reagent formation. While the nonradical pathway T2 leads to retention of the configuration, the radical pathway T4 gives racemization. Our calculations suggest the way that T2 can be enhanced, which should be of significance to prompt new synthesis approaches for the preparation of chiral Grignard reagents. |
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