A route to dicyanomethylene pyridines and substituted benzonitriles utilizing malononitrile dimer as a precursor |
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Authors: | Helmy Noha M El-Baih Fatma E M Al-Alshaikh Monirah A Moustafa Moustafa S |
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Affiliation: | Women Students-Medical Studies & Sciences Sections, Chemistry Department, College of Science, King Saud University, Riyadh, KSA, P.O. Box 22452, Riyadh 11495, Saudi Arabia. Elnagdinoha@yahoo.com |
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Abstract: | The conditions of the reaction of malononitrile dimer with enaminones and arylidenemalononitrile could be adapted to yield either pyridines or benzene derivatives. A new synthesis of pyrido[1,2-a]pyrimidines from the reaction of malononitrile dimer 1 and 2-phenyl-3-piperidin-1-yl-acrylonitrile (11) is described. Compound 1 condensed with DMFDMA to yield an enaminonitrile that reacted with hydrazine hydrate to yield N',4,6-triamino-2H-pyrazolo[3,4-b]pyridine-5-carboxamidine (17). |
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