Facile Synthesis of (±)-2,6-Dimethethyl-6-hydroxy-2,7-octadienoic Acid and its Methyl Ester and Amide (Acacialactam) |
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| Authors: | Chusheng Huang Xihui Chen Ying Li Yulin Li Hongxing Liu |
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| Affiliation: | 1. Institute of Applied Chemistry, Guangxi teachers College Nanning 530001;2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000;3. Department of Chemistry, Guangxi University, Nanning 530004 |
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| Abstract: | The monoterpenoid acid 1, which is a component of some traditional medicine such as Gymnocladus chinensis baillon in glycoside form,1 was recently isolated from Artemisia sieberi in Iran in free form.2. Its structure has been established to be (E)-2,6-dimethyl-6-hydroxy-2,7-octadienoic acid (1) by chemical and spectroscopic analysis. Its methyl ester derivative 2,was isolated from the antibacterial extracts of the leaves of Piper aduncum3 as well. Acacialactam, a natural product isolated from the seeds of Acacia concinna DC.(Legunninosae) used in folk medicine of several tropical countries for treating some skin diseases, was assigned structure 4 by Sekine et al4 on the basis of its physical and spectral properties. |
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