A General and Facile Synthesis of l,3-Diaryl-4-pyrazoleacetic Acids and Its Application in the Synthesis of SDZ RGU 825

1,3-Diaryl-4-pyrazoleacetic acids and derivatives exhibit multiple biological activities.¹ For example, Lonazolac^® is listed in Merck index as an antiinflammatory and analgesic agent. We were interested in this type of compounds for their potential applications in anti-diabetics. One of the leading candidates, SDZ RGU 825,has been shown to enhance whole-body glucose disposal without increasing insulin secretion. Therefore, it was developed for treatment of "non-insulin-dependent diabetes mellitus",the type Ⅱ diabetics.