The Total Synthesis of (±)-13-Hydroxyneocembrene |
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| Authors: | Yacheng Xing Wen Cen Ying Li Jiong Lan Yulin Li |
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| Affiliation: | 1. Department of Chemistry, Qingdao University, Qingdao 266071;2. National Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000 |
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| Abstract: | (13S)-hydroxyneocembrene(18), a cembranoid which was isolated in 1988 from soft coral Sarcophyton trocheliophorum1, has been shown to be an effective inductor of the release of labeled glucose from the lecithincholesterol liposomes and have cytostatic activities2. The geometrical structure and absolute configuration of 18 have been defined to be 1S, 2E, 7E, 11E, 13S. Herein, we report the total synthesis of (±)-13hydroxyneocembrene(18). |
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