Piezoelectric Genosensor Based on PCR Amplification and Application to Detection of Human Papillomavirus Oncogene |
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Authors: | MO Zhi-Hong LIU Jian-Hui XUE Qiang FU Wei-Ling |
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Institution: | 1. Department of Applied Chemistry, Chongqing University, Chongqing, 400044, PR China;
2. Medical Laboratory, Southwestern Hospital, Third Military Medical University, Chongqing, 400038, PR China |
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Abstract: | This report presents a new concept of genosensor based on polymerase chain reaction (PCR) amplification with in-situ piezoelectric micro-mass measurement. Though there are increasing reports on DNA hybridization sensors based on electrochemical, optical and piezoelectric transducers with advantages such as simplicity and cost-effectiveness, the sensitivity of genosensors developed so far could not match with the PCR technique, which is well-known to be generated in abundance. |
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