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Exploring an expedient IMDA reaction approach to construct the guanacastepene core |
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| Authors: | Li Chuang-Chuang Liang Shuang Zhang Xin-Hao Xie Zhi-Xiang Chen Jia-Hua Wu Yun-Dong Yang Zhen |
| Institution: | Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, College of Chemistry, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Science, Peking University, Beijing 100871, China. |
| Abstract: | Construction of the 5-7-6] tricyclic core of guanacastepenes was attempted by using the intramolecular Diels-Alder (IMDA) reaction and Me(3)Al-mediated ring opening of the oxabridge as key synthetic steps. The illustrated chemistry demonstrated a synthetic feasibility to build up the framework of guanacastepenes by the IMDA reaction. reaction: see text] |
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