Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry |
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Authors: | Myung S W Chang Y J Min H K Kim D H Kim M Kang T K Yoo E A Sohn Y T Yim Y H |
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Affiliation: | Doping Control Center, Korea Institute of Science and Technology, Seoul. swmyung@kist.re.kr |
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Abstract: | Using the high performance liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS) technique, together with established trends from the literature, the structures of metabolites and impurities of amiodarone, an anti-arrhythmic drug, have been assigned. By comparing analyses of products of incubation with rat liver microsomes with controls in which glucose 6-phosphate dehydrogenase was omitted, metabolites could be distinguished from impurities. Structures for the two proposed metabolites and four impurities are proposed. |
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