Interaction of cobalt(III) polypyridyl complexes containing asymmetric ligands with DNA |
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| Authors: | Penumaka Nagababu Mynam Shilpa Sirasani Satyanarayana Jeevigunta Naveena Lavanya Latha Kilampalli Shivaramasastri Karthikeyan Medisetti Rajesh |
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| Affiliation: | (1) Department of Chemistry, Osmania University, Hyderabad, Andhra Pradesh, India;(2) Dr. Reddy’s Laboratory, Discover Research, Miyapur, Hyderabad, Andhra Pradesh, India;(3) Department of Microbiology, Osmania University, Hyderabad, Andhra Pradesh, India;(4) Department of Biochemistry, Osmania University, Hyderabad, Andhra Pradesh, India |
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| Abstract: | Four asymmetric cobalt(III) complexes, [Co(bpy)2(aip)]3+, [Co(bpy)2(pyip)]3+, [Co(phen)2(aip)]3+, and [Co(phen)2(pyip)]3+ (bpy = 2,2,bipyridine, phen = 1,10-phenathroline), (pyip = 2-(1-pyrenyl)-1H-imidazo[4,5-f][phen], (aip = 2-(9-anthryl)-1H-imidazo[4,5,-f][phen], have been synthesized and characterized. Their interaction with calf thymus DNA (CT-DNA) was investigated by physico-chemical methods and photocleavage. The size and shape of the ligands have a marked effect on the DNA-binding affinity of the complexes. Irradiation of pBR322 DNA with these novel cobalt(III) complexes results in nicking of the plasmid DNA. Toxicity and induced cell death investigations revealed that the complexes of pyip had higher toxicity than those of aip. Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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