尖山橙生物碱的研究

从尖山橙(Melodinus fusiformis)全植物中分得15个生物碱, 其中三个为新生物碱,采用波谱分析和化学方法,它们的结构分别鉴定为: 11,19(R)-dihydroxy tabersonine,11-hydroxy-14,15a-epoxy tabersonine 和 scandine N~b-oxide。其余12个为已知生物碱: scandine, moloscandonine, 10-hydroxysoandine, Kopsinine,15α-hydroxydopsinine, venalstonine, tabersonine,11-methoxytabersonine, 11-hydroxytabersonine, tubotaiwine(13), vindolinine (14)和deacetylpicraline。新生物碱1和2分别显示有明显的抗生育和抗肿瘤的作用。

Study on the alkaloids of Melodinus fusiformis

Fifteen alkaloids have been isolated from Melodinus fusiformis (Apocynaceae), a plant used in Chinese folk medicine for the treatment of rheumatic heart disease, and invigorating the circulation of blood. Three of them have been established as new alkaloids: 11,19(R)-dihydroxytabersonine (I), 11-hydroxy-14,15a-epoxy tabersonine (II) and scandine Nb-oxide (III). The 12 known alkaloids were scandine, meloscandonine, 10-hydroxyscandine, kopsinine, 15a-hydroxy kopsinine, venalstonine, tabersonine, 11-methoxytabersonine, 11-hydroxytabersonine, tubotaiwine, vindolinine, and deacetylpicraline. Alkaloids I and II show significant spermatocidal and antitumor activity, resp.