| 番荔枝皂素(4S,5S)和(4S,5R)-Muricatacin的合成及Annonacin四氢呋喃段绝对构型的确证 |
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| 引用本文： | 姚祝军,张一兵,吴毓林.番荔枝皂素(4S,5S)和(4S,5R)-Muricatacin的合成及Annonacin四氢呋喃段绝对构型的确证[J].化学学报,1992,50(9):901-904. |
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| 作者姓名： | 姚祝军 张一兵 吴毓林 |
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| 作者单位： | 中国科学院上海有机化学研究所;中国科学院生命有机化学国家重点实验室 |
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| 摘 要： | 本文以L-谷氨酸为原料合成了(1S,5S)和(4S,5R)-Muricatacin,并以该两化合物的NMR和a]~D数据确证了Annonacin中四氢呋喃段的四个手性中心为(15R,16R,19R,20R).
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| 关 键 词： | 核磁共振谱法 还原 谷氨酸 四氢呋喃 P 绝对构型 番荔枝皂素 |
Synthesis of annonaceous acetogenin (4S,5S) and (4S,5R)-muricatacin as well as confirmation of absolute configuration of the tetrahydrofuran segment of annonacin |
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| Abstract: | The synthesis of (+)-(4S,5S)-muricatacin (I) and its (4S,5R) isomer from L-(+)-glutamic acid as starting material is reported. Natural muricatacin is confirmed as a threo mixture major in (4R,5R) configuration and hence the absolute configuration of the THF segment of annonacin is (15R,16R,19R,20R) by comparison of the NMR and optical rotations. |
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| Keywords: | NMR SPECTROMETRY REDUCTION GLUTAMIC ACID TETRAHYDROFURAN P ABSOLUTE CONFIGURATION |
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