Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp |
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Authors: | Hussain Hidayat Krohn Karsten Schulz Barbara Draeger Siegfried Nazir Mamona Saleem Muhammad |
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Affiliation: | Department Chemie, Universit?t Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany. |
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Abstract: | Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae. |
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