黄酮化合物的合成新方法

黄酮类化合物具有广泛而重要的生物活性和药理作用,其化学合成研究受到普遍重视.经典的合成方法主要是查耳酮路线和β-丙二酮路线.近年来有很多新技术、新方法在黄酮化合物合成中得到了巧妙的应用.对近年来出现的新的改进的Baker-Venkataraman法、催化羰基化闭环法以及其他合成黄酮化合物的新方法作了介绍.

New Synthetic Methods of Flavones

Flavones are a group of naturally occurring compounds that widely distributed in the plant kingdom, and have been associated with a wide variety of biological and pharmaceutical activities. Traditionally there are two main methods available to synthesize flavones, i.e., the chalcone route and Baker-Venkataraman method. Recently, many new methods have been discovered for the synthesis of flavones. The modified Baker-Venkataraman methods and carbonylative annulation of iodophenol acetate, and other new methods for constructing flavones are reviewed in this paper.