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Preparation of 1-amino-4-methylpiperazine |
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| Authors: | P M Kushakova A N Chernobroviy V A Kuznetsov A V Garabadgiu |
| Institution: | (1) Saint-Petersburg State Technical University, 190013 Saint-Petersburg, Russia;(2)  Olainfarm , LV-2114 Riga, Latvia |
| Abstract: | The selectivity of the formation of N-di(2-chloroethyl)methylamine in reactions with various chlorinating agents has been investigated and the optimum chlorinating agent has been found. 1-Amino-4-methylpiperazine has been obtained for the first time by the cyclization of N-di(2-chloroethyl)methylamine with aqueous hydrazine. A possible mechanism has been proposed for the cyclization reaction.Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 12, pp. 1794–1797, December, 2004. |
| Keywords: | 1-amino-4-methylpiperazine haloalkylamines N N-di(2-chloroethyl)methylamine N-(2-chloroethyl)-N-methylaziridinium chloride N-(2-chloroethyl)-N-(2-hydrazinoethyl)methylamine |
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