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Convergent synthesis of a complex oxime library using chemical domain shuffling |
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| Authors: | Su Shun Acquilano Dayle E Arumugasamy Jeevanandam Beeler Aaron B Eastwood Erin L Giguere Joshua R Lan Ping Lei Xiaoguang Min Geanna K Yeager Adam R Zhou Ya Panek James S Snyder John K Schaus Scott E Porco John A |
| Affiliation: | Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA. |
| Abstract: | [reaction: see text] The synthesis of a complex hybrid oxime library is reported utilizing convergent ligation of alkoxyamine and carbonyl monomers via "chemical domain shuffling". Initial biological screening of the library against human small cell lung carcinoma (A549) cells led to the identification of a novel hybrid dimer in contrast to the corresponding monomeric compounds which were found to be inactive. |
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