磺胺二甲嘧啶分子印迹聚合物制备与光谱特性

本研究以磺胺二甲嘧啶为模板分子，甲基丙烯酸为功能单体，低温紫外引发聚合制备分子印迹聚合物,用紫外光谱法对磺胺二甲嘧啶与甲基丙烯酸的结合作用及磺胺二甲嘧啶印迹聚合物的静态吸附性能和选择性能进行研究，试验结果表明,溶液中的功能单体与印迹分子之间产生了结合作用;与空白印迹聚合物相比,以甲基丙烯酸为功能单体、磺胺二甲嘧啶为模板的分子印迹聚合物展现了较高的结合容量,与其他结构类似的底物磺胺异唑相比,磺胺二甲嘧啶分子印迹聚合物对磺胺二甲嘧啶模板分子显示出明显的选择性和特异性，静态分配系数K_D可达282.3 mg·mL-1,分离因子α可达3.9，并预测磺胺二甲嘧啶分子印迹聚合物结合机理。分析了甲基丙烯酸、二甲基丙烯酸乙二醇酯和磺胺二甲嘧啶分子印迹聚合物的红外谱图，研究结果表明制备的磺胺二甲嘧啶印迹聚合物中CC双键峰很小，并且功能键羧酸键没有明显变化，经交联聚合得到的聚合物确实存在可以同印迹分子相互作用的化学基团。

Preparation and Spectral Characteristic of Molecularly Imprinted Polymers for Sulfamethazine

Molecularly imprinted polymers(MIPs) were synthesized,which was initiated by UV photo-induction at low temperature,with sulfamethazine(SM2) was used as template,methacrylic acid(MAA) as monomer,and ethylene glycol dimethylacrylate (EGDMA) as crosslinker. By UV spectrometry the authors compared the combination action on sulfamethazine with MAA and researched the static adsorption ability and selective recognition of the molecularly imprinted polymers. The results showed that the combination action of functional monomer with template molecules was produced,sulfamethazine imprinted polymers using methacrylic acid as monomer had higher affinity capability than NMIP and comparatively similar structure substrate of sulfisoxazole(SIZ),while SM2 imprinted polymers could specifically recognize the corresponding imprinted molecules. The static adsorption modulus of SM2 imprinted polymer was 282.3 mg·mL-1 and the separate factor was 3.9. Then,the prediction imprinting principle of sulfamethazine template polymer was given. The infrared spectra of methacrylic acid (MAA) and ethylene glycol dimethylacrylate (EGDMA) and MIPs of SM2 were analysed. It was found that the absorbability peak of CC function group in the IMPs turned out to be very low,but the function group of carboxylic acid in the IMPs did not markedly change. The results showed that there were some functional groups in MIPs which could interact with the template.