Synthesis of 1,2,3-triazole derivatives and in vitro antifungal evaluation on Candida strains |
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Authors: | Lima-Neto Reginaldo G Cavalcante Nery N M Srivastava Rajendra M Mendonça Junior Francisco J B Wanderley Almir G Neves Rejane P dos Anjos Janaína V |
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Institution: | Laboratório de Micologia Médica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco-UFPE, 50670-901 Recife, PE, Brazil. |
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Abstract: | 1,2,3-Triazoles have been extensively studied as compounds possessing important biological activities. In this work, we describe the synthesis of ten 2-(1-aryl-1H-1,2,3-triazol-4-yl)propan-2-ols via copper catalyzed azide alkyne cycloaddition (CuAAc or click chemistry). Next the in vitro antifungal activity of these ten compounds was evaluated using the microdilution broth method against 42 isolates of four different Candida species. Among all tested compounds, the halogen substituted triazole 2-1-(4-chlorophenyl)-1H-(1,2,3)triazol-4-yl]propan-2-ol, revealed the best antifungal profile, showing that further modifications could be done in the structure to obtain a better drug candidate in the future. |
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