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Peptide synthesis : Part 10. Use of pentafluorophenyl esters of fluorenylmethoxycarbonylamino acids in solid phase peptide synthesis |
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| Affiliation: | 1. Departamento de Química, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Asunción, 2189 Campus Universitario San Lorenzo, Paraguay;2. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Casilla de Correo 16, Sucursal 4, 1900 La Plata, Argentina;1. Case Western Reserve School of Medicine, Ohio;2. Department of Dermatology, Cleveland Clinic Foundation, Ohio |
| Abstract: | The application of fluorenylmethoxycarbonyl-amino-acid pentafluorophenyl esters to solid phase peptide synthesis under polar reaction conditions is described. Reaction rates are increased in the presence of l-hydroxybenzotriazole. The technique is illustrated by preparation of decapeptide and dodecapeptide sequences. |
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