| New Stereoselective Synthesis of 4-Butyl-α-agarofuran |
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| 引用本文： | ChunLI DaLiYIN 张晋文 XiangHongWU JiYuGUO HuiQinHUANG.New Stereoselective Synthesis of 4-Butyl-α-agarofuran[J].中国化学快报,2003,14(9):881-882. |
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| 作者姓名： | ChunLI DaLiYIN 张晋文 XiangHongWU JiYuGUO HuiQinHUANG |
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| 作者单位： | Chun LI，Da Li YIN，Hui Qin HUANG，Xiang Hong WU，Ji Yu GUO
Institute of Materia Medica，Chinese Academy of Medical Sciences & Peking Union Medical College，Beijing 100050 |
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| 摘 要： | A potent anxiolytic 4-butyl-α-agarofuran (AF-5) was synthesized from ( )dihydrocarvone. Acid catalyzed hydration of ( )dihydrocarvone and interconversion with β-O-ketone 8 and the key intermediate α,β-unsaturated ketone 5 made this synthesis more practical.
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| 关 键 词： | 立体选择性合成 4-丁基-α-琼脂呋喃 二氢黄蒿萜酮 催化水合作用 中枢神经系统 药理活性 抗焦虑药 |
New Stereoselective Synthesis of 4-Butyl-α-agarofuran |
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| Chun LI,Da Li YIN,Hui Qin HUANG,Xiang Hong WU,Ji Yu GUO.New Stereoselective Synthesis of 4-Butyl-α-agarofuran[J].Chinese Chemical Letters,2003,14(9):881-882. |
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| Authors: | Chun LI Da Li YIN Hui Qin HUANG Xiang Hong WU Ji Yu GUO |
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| Abstract: | A potent anxiolytic 4-butyl-α-agarofuran (AF-5) was synthesized from (+)dihydro-carvone. Acid catalyzed hydration of (+)dihydrocarvone and interconversion with β-O-ketone 8and the key intermediate α,β-unsaturated ketone 5 made this synthesis more practical. |
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| Keywords: | AF-5 stereoselective synthesis |
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