A Sensitive Electrochemical Sensor for Moxifloxacin Hydrochloride Based on Nafion/Graphene Oxide/Zeolite Modified Carbon Paste Electrode |
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| Authors: | Amany M Fekry Soha A Abdel-Gawad Shereen M Azab Alain Walcarius |
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| Institution: | 1. Chemistry Department, Faculty of Science, Cairo University, Giza, 12613 Egypt.;2. Pharmaceutical Chemistry Dept., National Organization for Drug Control and Research [NODCAR], 6 Abu Hazem Street, Pyramids Ave, 29, Giza, postcode is missing Egypt.;3. Laboratoire de Chimie Physique et Microbiologie pour les Matériaux et l'Environnement (LCPME), UMR 7564 CNRS –, Université de Lorraine, 405 rue de Vandoeuvre, 54600 Villers-les-Nancy, France |
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| Abstract: | A carbon paste electrode (CPE) modified with Nafion, Graphene oxide and zeolite has been prepared and characterized, and the resulting Nafion/Graphene oxide/Zeolite modified carbon paste electrode (N/G/Z/MCPE) has been applied to the electrochemical detection of Moxifloxacin hydrochloride (MOXI). It exhibited a good electrocatalytic activity in phosphate buffer (optimum at pH 7.4), as pointed out by cyclic voltammetry (CV), and N/G/Z/MCPE can be exploited for MOXI detection by chronoamperometry, electrochemical impedance spectroscopy and differential pulse voltammetry. This latter was the most sensitive one and gave rise to a linear calibration curve in the 0.04 to 250 μM concentration range, with limits of detection and qualification estimated at 1.0 nM and 3.3 nM, respectively. Contrary to previous electrochemical sensors for MOXI (e. g., CPE modified with metal nanoparticles), this new sensor can be used for multiple successive analyses without needing to refresh its surface. |
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| Keywords: | Moxifloxacin Hydrochloride Carbon Paste Electrode Nafion Graphene Oxide Zeolite |
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