Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis |
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| Authors: | Chirlene Nascimento Botelho Daniele Pavão e Pavão Flávio Santos Damos Rita de Cássia Silva Luz |
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| Affiliation: | Department of Chemistry, Federal University of Maranhão, 65080-805 São Luís, MA, Brazil |
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| Abstract: | The present work describes the development of a photoelectrochemical sensor based on titanium dioxide, cadmium telluride quantum dots and the tris (2,2′-bipyridyl) ruthenium(II) chloride complex for detection of Isoniazid (INH). The Ru(bpy)32+/CdTe-QDs/TiO2/FTO photoelectrochemical platform was characterized by scanning electrochemical microscopy, electrochemical impedance spectroscopy and amperometry. The photoelectrochemical sensor presented two linear ranges for INH concentrations ranging from 0.5 to 150 μmol L−1 and 150 to 1270 μmol L−1, with a theoretical detection limit of 0.02 μmol L−1. The sensor was successfully applied for the determination of INH in drugs samples used in the treatment of tuberculosis. |
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| Keywords: | PEC sensor quantum dots Ruthenium complex isoniazid. |
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