Photoelectrochemical Sensor for Isoniazid: Application in Drugs Used in the Treatment of Tuberculosis |
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Authors: | Chirlene Nascimento Botelho Daniele Pavão e Pavão Flávio Santos Damos Rita de Cássia Silva Luz |
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Institution: | Department of Chemistry, Federal University of Maranhão, 65080-805 São Luís, MA, Brazil |
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Abstract: | The present work describes the development of a photoelectrochemical sensor based on titanium dioxide, cadmium telluride quantum dots and the tris (2,2′-bipyridyl) ruthenium(II) chloride complex for detection of Isoniazid (INH). The Ru(bpy)32+/CdTe-QDs/TiO2/FTO photoelectrochemical platform was characterized by scanning electrochemical microscopy, electrochemical impedance spectroscopy and amperometry. The photoelectrochemical sensor presented two linear ranges for INH concentrations ranging from 0.5 to 150 μmol L?1 and 150 to 1270 μmol L?1, with a theoretical detection limit of 0.02 μmol L?1. The sensor was successfully applied for the determination of INH in drugs samples used in the treatment of tuberculosis. |
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Keywords: | PEC sensor quantum dots Ruthenium complex isoniazid |
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