Zn Nanoparticles Modified Screen Printed Carbon Electrode as a Promising Sensor for Insulin Determination |
| |
| Authors: | Dr. Ivana Šišoláková Jana Hovancová Frederika Chovancová Prof. Renáta Oriňaková Dr. Iveta Maskaľová Prof. Andrej Oriňak Prof. Jozef Radoňak |
| |
| Affiliation: | 1. Department of Physical Chemistry, University of P.J. Šafárik in Košice, Moyzesova 11, 040 01 Košice, Slovakia;2. Department of Nutrition, Dietetics, and Animal Breeding, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia;3. Faculty of Medicine, University of P.J. Šafárik in Košice, Trieda SNP 1, 040 01 Košice, Slovakia |
| |
| Abstract: | Screen printed carbon electrodes (SPCEs) modified by a combination of chitosan, multi walled carbon nanotubes (MWCNTs) and zinc nanoparticles (ZnNPs) were studied for the first time as a suitable candidate for non-enzymatic insulin determination. In an effort to find the most suitable modification for electrochemical insulin determination, the stability, analytical characteristics, and selectivity were determined. The results confirmed that the ZnNPs/chitosan-MWCNTs prepared with the Zn deposition time of 45 s displayed the best electrocatalytic activity towards insulin oxidation in a wide linear concentration range (0.5 μM to 5 μM), with low limit of detection and high sensitivity. |
| |
| Keywords: | insulin diabetes mellitus zinc nanoparticles carbon electrodes electrochemical sensor |
|
|
