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A New Voltammetric Approach for Electrochemical Determination of Lamotrigine in Pharmaceutical Samples |
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| Authors: | Anton A. Ciucu Mihaela Buleandră Tatiana Ciurea Vlad N. Stoica Cristian D. Ştefanescu Adela Ciobanu |
| Affiliation: | 1. University of Bucharest, Faculty of Chemistry, Department of Analytical Chemistry, 90-92 Panduri Av., 050663 Bucharest, Romania;2. Bagdasar-Arseni Emergency Clinical Hospital, Functional Neurosurgery Department, EEG Epilepsy Research Section), Berceni Av., 041915 Bucharest, Romania;3. National Institute of Aeronautical and Aerospace Medicine Gen. Dr. Victor Anastasiu, 88 Mircea Vulcanescu Str., Bucharest, Romania;4. University of Medicine and Pharmacy, Carol Davila, Department of Psychiatry, Bucharest, Romania |
| Abstract: | A new linear sweep voltammetric method for quantitative lamotrigine (LMT) determination based on an electrochemically pre-treated pencil graphite electrode (PGE*) is presented. Response characteristics of the PGE* toward the mentioned compound were investigated by cyclic voltammetry and linear sweep voltammetry. The quantitative determination of LMT revealed a wide linear range of 2.5 ⋅ 10−5–1.0 ⋅ 10−3 M with a detection limit of 1.94 ⋅ 10−5 M. The method was used successfully for LMT determination in a pharmaceutical formulation. |
| Keywords: | disposable electrode voltammetry lamotrigine pharmaceutical formulation |