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Recent advances in paper-based preconcentrators by utilizing ion concentration polarization |
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| Authors: | Meng Zhiyue Yuan Xichen Ren Li Yang Yang Feng Huicheng Shang Peng |
| Affiliation: | 1. School of Life Sciences, Northwestern Polytechnical University, Xi'an, P. R. China;2. School of Life Sciences, Northwestern Polytechnical University, Xi'an, P. R. China Research and Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen, P. R. China Key Laboratory for Space Bioscience and Biotechnology, Institute of Special Environment Biophysics, Northwestern Polytechnical University, Xi'an, P. R. China;3. Ministry of Education Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing, P. R. China;4. Unmanned System Research Institute, Northwestern Polytechnical University, Xi'an, P. R. China |
| Abstract: | One of the most cited limitations of biochemical detection is its poor sensitivity, owing to the relatively high complexity of micro-samples. Moreover, some samples cannot be easily self-replicated and their abundance cannot be increased through traditional technologies. Therefore, the preconcentration of low-abundance samples is a key requirement for microfluidic biological analysis. In recent years, the ion-concentration polarization phenomenon has aroused widespread interest in the application of microfluidic technology. In addition, paper-based materials are readily available, easy to modify, and exhibit good hydrophilicity. The study of the ion-concentration polarization preconcentration of micro-samples in paper-based microfluidic chips is of considerable significance. In this review, we discuss the development and applications of ion-concentration polarization paper-based preconcentrator in the past 5 years, with emphasis on key progresses in chip fabrication and performance optimization under different conditions. The current needs and development prospects in this field have also been discussed. |
| Keywords: | Ion concentration polarization Micro-sample Preconcentration Paper-based preconcentrator |