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Determination of Paracetamol Based on 3-Amino-4H-1,2,4-triazole Coated Glassy Carbon Surface in Pharmaceutical Sample
Authors:Demet Uzun
Affiliation:Gazi University, Faculty of Science, Department of Chemistry, 06500 Ankara/, Turkey
Abstract:In this present study, to determine paracetamol, an electroanalytical method is presented using differential pulse voltammetry (DPV) at 3-amino-4H-1,2,4-triazole (3AT) coated glassy carbon (GC) electrode. The electrochemical characterization and electron transfer behavior of this prepared electrode in the mixture of K4[Fe(CN)6]/K3[Fe(CN)6] contains 0.1 M KCl was confirmed by using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. Furthermore, scanning electron microscopy (SEM) was used to observe morphological structures of the bare and modified surfaces. The effect of pH was studied on the redox reaction of paracetamol in phosphate buffer in the range of pH 3.0–9.0. The limit of detection was 0.043 μM (3 s/m) for 3AT-GC electrode. The developed electrode was successfully utilized in pharmaceutical samples.
Keywords:Modified electrode  3-amino-4H-1,2,4-triazole  paracetamol  pharmaceutical.
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