Flow-through enzymatic reactors using polymer monoliths: From motivation to application |
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| Authors: | Yuhong Mao Rong Fan Renkuan Li Xiuyun Ye Ulrich Kulozik |
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| Institution: | 1. Fujian Key Laboratory of Marine Enzyme Engineering, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian, P. R. China;2. Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Giessen, Germany;3. Chair of Food and Bioprocess Engineering, Technical University of Munich, Freising-Weihenstephan, Germany |
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| Abstract: | The application of monolithic materials as carriers for enzymes has rapidly expanded to the realization of flow-through analysis and bioconversion processes. This expansion is partly attributed to the absence from diffusion limitation in many monoliths-based enzyme reactors. Particularly, the relatively ease of introducing functional groups renders polymer monoliths attractive as enzyme carriers. After summarizing the motivation to develop enzymatic reactors using polymer monoliths, this review reports the most recent applications of such reactors. Besides, the present review focuses on the crucial characteristics of polymer monoliths affecting the immobilization of enzymes and the processing parameters dictating the performance of the resulting enzymatic reactors. This review is intended to provide a guideline for designing and applying flow-through enzymatic reactors using polymer monoliths. |
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| Keywords: | Analytic applications Bioconversions Flow biocatalysis Polymer monolith Processing parameters |
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