A Close-to-Aromatize Approach for the Late-Stage Functionalization through Ring Closing Metathesis |
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| Authors: | Boris Lozhkin Thomas R. Ward |
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| Affiliation: | Department of Chemistry, University of Basel, Building 1096, Mattenstrasse 24a, Biopark Rosental, CH-4058 Basel, Switzerland |
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| Abstract: | An efficient approach for the synthesis of monosubstituted aromatic compounds relying on a ring-closing metathesis followed by spontaneous 1,2-elimination is presented. The efficiency for late-stage functionalization is highlighted in various solvents (up to 920 TON). This approach is compatible with strained cycles and other multiple bonds in the substrate. |
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| Keywords: | elimination late-stage functionalization metathesis ring closing metathesis |
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