A Novel Redox-free Immunosensor Concept Based on Cobalt Phthalocyanine@carbon Nanotubes Pseudocapacitor for Cardiac B-type Natriuretic Peptide Detection |
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| Authors: | Vicente P A Landim Bárbara V M Silva Dário C Sobral Filho Rosa F Dutra |
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| Institution: | 1. Biomedical Engineering Laboratory, Department of Biomedical Engineering, Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235., Recife-PE, 50670-901 Brazil;2. Cardiac Emergency of Pernambuco (PROCAPE)/State University of Pernambuco, R. dos Palmares, Recife-PE, 74970-240 Brazil |
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| Abstract: | B-type natriuretic peptide (BNP) is a selective biomarker for cardiac diagnosis and prognosis of patients with cardiac insufficiency or heart failure, which means the pump function of cardiac muscle is reduced. A pseudocapacitive immunosensor was developed based on faradaic currents generated by a reduction-reaction with a metallocyanine modified-carbon nanotube surface. This technique is based on changes in interface by antigen-antibody interactions, which perturbs the dependent-diffusion potential reducing the charge transfers proportionally to the BNP captured. This new concept allows new perspectives for point-of-care tests since it is simpler and faster to manage with direct measurements of samples than conventional immunosensors. |
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| Keywords: | reagentless cobalt phthalocyanine immunosensor type-B natriuretic peptide heart failure |
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