Influence of thionin on the structure of a bilayer and on the intermembrane exchange of lipid material

It has been shown that in lipid dispersions thionin causes the formation of heterogeneous structures with the production of lipid-enriched clusters melting at elevated temperatures. This effect of thionin depends on the type of acidic lipid. It has also been established that thionin causes the aggregation and intermembrane exchange of lipid material between two populations of liposomes possessing individual thermodynamic characteristics.A. S. Sadykov Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Fax 627071. Brigham Young University, Provo, Utah, USA. Translated from Khimiya Prirodnykh Soedinenii, No. 1, pp. 78–82, January–February, 1994.