An active bubble trap and debubbler for microfluidic systems |
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Authors: | Skelley Alison M Voldman Joel |
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Institution: | Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. |
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Abstract: | We present a novel, fully integrated microfluidic bubble trap and debubbler. The 2-layer structure, based on a PDMS valve design, utilizes a featured membrane to stop bubble progression through the device. A pneumatic chamber directly above the trap is evacuated, and the bubble is pulled out through the gas-permeable PDMS membrane. Normal device operation, including continuous flow at atmospheric pressure, is maintained during the entire trapping and debubbling process. We present a range of trap sizes, from 2 to 10 mm diameter, and can trap and remove bubbles up to 25 muL in under 3 h. |
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