| MOLECULAR POLARITY IN DNA-PROTEIN RECOGNITION——THE CASE OF λ-REPRESSOR-OPERATOR SYSTEM |
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| 引用本文： | 王家槐,MITCHELL LEWIS.MOLECULAR POLARITY IN DNA-PROTEIN RECOGNITION——THE CASE OF λ-REPRESSOR-OPERATOR SYSTEM[J].中国科学B辑(英文版),1985(3). |
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| 作者姓名： | 王家槐 MITCHELL LEWIS |
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| 作者单位： | Institute of Biophysics，Academia Sinica，Beijing，Smith Kline and French Laboratories，Philadelphia，Pennsylvania 19101，USA |
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| 摘 要： | The charge distribution of λ-repressor suggests that the molecular electrostatic polarity may accelerate the non-specific binding of the protein to the DNA molecule. The repressor molecule has a patch of positive charge within the first 26 residues which may contribute a non-specific binding surface. In addition, electrostatics may play an important role and account for why proteins form and use dimers in many specific DNA-protein recognition processes.
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